Human Coagulation Factor Ⅷ

[Dosage Form] 

This product should be white, milky white loose body, after reconstitution, it should be colorless and clear liquid, with slight opalescence.

[Indications] 

This product has a corrective effect on coagulation dysfunction caused by lack of human coagulation factor Ⅷ, and is mainly used to prevent and treat bleeding symptoms caused by hemophilia A and acquired factor Ⅷdeficiency, and surgical bleeding treatment of such patients.

[Specifications] 

[Usage and dosage]

Usage: This product is designed for intravenous infusion and should be used under the strict supervision of a clinician. Before use, the product and its diluent should be pre-warmed to 25-37 ° C, then the diluent is injected into the bottle according to the amount indicated on the bottle label, and gently shaken to completely reconstitute the product (be careful not to cause foam), then A blood transfusion device with a filter device is used for intravenous infusion, and the infusion rate is generally about 0 drops per minute. The product should be used immediately after reconstitution and lost within 1 hour.

Dosage: Dosage must refer to weight, presence of inhibitors, severity of bleeding and other factors.

The following formula can be used to calculate the dose: Required factor Ⅷ Unit (IU) / time = 0.5 × Patient weight (kg) × Factor to be promoted Ⅷ Activity level (normal%)

Example: Required factor Ⅷ Unit (IU) / times = 0.5 × 50 (kg) × 30 (%) = 750IU

Recommended dose：

1. Mild to moderate bleeding: single does 10~15IU/kg weight, which can improve the level of factor Ⅷ to 20~30% of normal person.

2. Sever bleeding or minor operation: to improve the level of factor Ⅷ to 30~50% of normal person, the initial dose shall be 15～25IU/kg weight. If needed, maintenance dose shall be 10～15IU/kg weight in each every 8~12 hours.

3. Hemorrhoea: lethal bleeding such as bleeding in oral cavity, urinary tract, and central nervous system or bleeding near vitals such as neck, throat, retroperitoneal and skeleton muscle: initial dose 40IU/kg weight, then giving the maintenance dose as 20～25IU/kg weight in each every 8~12 hours. Course of treatment shall be decided by doctors.

4. Operation: operation can only be done after the inhibitor of the coagulation factor Ⅷ has no abnormal increasing. when start the operation, the factor Ⅷ concentration in blood shall be 60~120% of the normal level. Normally, dosage before the operation shall be 30～40IU/kg weight. After the operation and within 4 days, factor Ⅷ shall be maintained as 60% of the normal person, and which can be decreased to 40% in the next 4 days.

5. Inhibitor reactiveplasmacytosis for acquired factor Ⅷ: large dose of coagulation factor Ⅷ shall be given, which is over one time for the dose used for hemophiliacs.